Dobutamine (hydrochloride)

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

多巴酚丁胺（盐酸盐）是一种儿茶酚胺，作为 β-肾上腺素能受体激动剂，具有有效的正性肌力作用。

Dobutamine (hydrochloride) is a catecholamine that acts as a β-adrenergic receptor agonist with potent positive inotropic effects.(In Vivo):Dobutamine hydrochloride has a rapid onset of action and a short half-life . Dobutamine hydrochloride (0.15-20 mg/kg; i.p.) results in subsequent increase in the left ventricular function and heart rate acceleration with an increasing dose in wildtype mice.Dobutamine hydrochloride results in significant inotropic, lusitropic, and chronotropic cardiac response with a high dose in wildtype mice. Low doses of Dobutamine hydrochloride significantly increases inotropic and lusitropic cardiac performance without chronotropic changes in the Tgαq*44 mice. Dobutamine hydrochloride increases heart rate only after high doses, but then inotropic and lusitropic cardiac functional reserve is lost. Dobutamine hydrochloride increases alveolar liquid clearance in ventilated rats by beta-2 receptor stimulation.

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Dobutamine hydrochloride has a rapid onset of action and a short half-life .Dobutamine hydrochloride (0.15-20 mg/kg; i.p.) results in subsequent increase in the left ventricular function and heart rate acceleration with an increasing dose in wildtype mice.Dobutamine hydrochloride results in significant inotropic, lusitropic, and chronotropic cardiac response with a high dose in wildtype mice.?Low doses of Dobutamine hydrochloride significantly increases inotropic and lusitropic cardiac performance without chronotropic changes in the Tgαq*44 mice.?Dobutamine hydrochloride increases heart rate only after high doses, but then inotropic and lusitropic cardiac functional reserve is lost.?Dobutamine hydrochloride increases alveolar liquid clearance in ventilated rats by beta-2 receptor stimulation. Animal Model:Tgαq*44 mice (heart failure models) Dosage:0.15 mg/kg, 0.5 mg/kg as a low dose, 1.5 mg/kg, 5 mg/kg, 20 mg/kg as a high dose Administration:Intraperitoneal injection Result:Induced different response in cardiac function on a low and high dose in mice with with heart failure.

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Angiogenesis

Adrenergic Receptor

Adrenergic Receptor

Others

Hemodynamic Instability

49745-95-1

337.84

C18H24ClNO3

>98% (HPLC)

DMSO:33 mg/mL (97.68 mM); H2O:20 mg/mL (59.20 mM; Need ultrasonic)

Cl.CC(CCc1ccc(O)cc1)NCCc1ccc(O)c(O)c1

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(-20℃)

With Ice Pack

≥ 2 years